alpha Actinin 4 anticorps (AA 1-50)

N° du produit ABIN7449956

L’anticorps Lapin Polyclonal anti-alpha Actinin 4 a été validé pour WB et IP. Il convient pour détecter alpha Actinin 4 dans des échantillons de Humain et Souris.

Aperçu rapide pour alpha Actinin 4 anticorps (AA 1-50) (ABIN7449956)

Antigène: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha Actinin 4 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-alpha Actinin 4 anticorps

Épitope: AA 1-50

Fonction: Rabbit anti-alpha Actinin 4/ACTN4 Antibody, Affinity Purified

Homologie: Rat,Bovine

Purification: Affinity Purified

Immunogène: Between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur alpha Actinin 4

Antigène: alpha Actinin 4 (ACTN4) (Actinin, alpha 4 (ACTN4))

Autre désignation: alpha Actinin 4/ACTN4

Sujet: Background: Alpha Actinin 4 / ACTN4 is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). It is probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). It is involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. It links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). alpha Actinin 4 / ACTN4 may also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778) [taken from the Universal Protein Resource (UniProt) O43707].

ID gène: 81

NCBI Accession: NP_004915

UniProt: O43707

Pathways: Proton Transport